ea0063p163 | Diabetes, Obesity and Metabolism 1 | ECE2019
Schweighofer Natascha
, Haudum Christoph W
, Schmidt Albrecht
, Kolesnik Ewald
, Colantonio Caterina R
, Pieske Burkert
, Pieber Thomas R
, Obermayer-Pietsch Barbara
The proline rich and Gla domain genes PRRG1-4 encode for short transmembrane proteins. PRRG proteins contain a Gla domain with glutamic acid residues which are gamma-carboxylated in a vitamin-K-depend manner. In a previous study, we were able to show a decrease in PRRG1 gene expression during intima thickening in atherosclerosis. In this study, we investigated the association of single nucleotide polymorphisms (SNPs) in the vitamin-K-dependent protein PRRG1 with cardiovascular...